mouse STUB1 Adenovirus
This is an Adenovirus expressing Mouse STUB1.
ADV-262523
Ad-m-STUB1
Ready-to-use Adenovirus expressing Mouse Stub1 (STIP1 homology and U-Box containing protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
0610033N24Rik; 2210017D18Rik; 2310040B03Rik; AW046544; Chip
Description (Vector)
E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation.
Gene ID
56424
Gene Name (Vector)
STIP1 homology and U-Box containing protein 1
Gene Symbol
Stub1
ORF Size (aa)
915
ORF Size (bp)
915 bp
RefSeq ID
NM_019719
RefSeq Synonyms
NM_019719, BC038939, BC027427,
Species
mouse
UniGene ID
Mm.277599
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.