mouse INVS Adenovirus
This is an Adenovirus expressing Mouse Invs.
ADV-262309
Ad-m-INVS
Ready-to-use Adenovirus expressing Mouse Invs (inversin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
inv; Nphp2
Description (Vector)
Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity).
Gene ID
16348
Gene Name (Vector)
inversin
Gene Symbol
Invs
ORF Size (aa)
2733
ORF Size (bp)
2733 bp
RefSeq ID
NM_010569
RefSeq Synonyms
NM_010569, NM_001281978, NM_001281977, BC126929,
Species
mouse
UniGene ID
Mm.317706
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.