mouse HIF1AN Adenovirus
This is an Adenovirus expressing Mouse Hif1an.
ADV-261290
Ad-m-HIF1AN
Ready-to-use Adenovirus expressing Mouse Hif1an (hypoxia-inducible factor 1, alpha subunit inhibitor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2310046M24Rik; A830014H24Rik; FIH; FIH1
Description (Vector)
Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.
Gene ID
319594
Gene Name (Vector)
hypoxia-inducible factor 1, alpha subunit inhibitor
Gene Symbol
Hif1an
ORF Size (aa)
1050
ORF Size (bp)
1050 bp
RefSeq ID
NM_176958
RefSeq Synonyms
NM_176958, BC130013,
Species
mouse
UniGene ID
Mm.145278
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.