mouse EIF2AK2 Adenovirus
This is an Adenovirus expressing Mouse Eif2ak2.
ADV-258182
Ad-m-EIF2AK2
Ready-to-use Adenovirus expressing Mouse Eif2ak2 (eukaryotic translation initiation factor 2-alpha kinase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2310047A08Rik; 4732414G15Rik; AI467567; AI747578; Pkr; Prkr; Tik
Description (Vector)
Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity: phosphorylates CDK1 upon DNA damage. CDK1 phosphorylation triggers CDK1 polyubiquitination and subsequent proteolysis, thus leading to G2 arrest.
Gene ID
19106
Gene Name (Vector)
eukaryotic translation initiation factor 2-alpha kinase 2
Gene Symbol
Eif2ak2
ORF Size (aa)
1548
ORF Size (bp)
1548 bp
RefSeq ID
NM_011163
RefSeq Synonyms
NM_011163, BC016422,
Species
mouse
UniGene ID
Mm.378990
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.