mouse CD22 Adenovirus

Name 
Ad-m-CD22
Cat No 
ADV-254969
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Mouse Cd22.

ADV-254969
Ad-m-CD22

Ready-to-use Adenovirus expressing Mouse Cd22 (CD22 antigen). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
A530093D23;B-cell receptor CD22;BL-CAM;B-lymphocyte cell adhesion molecule;CD antigen CD22;Lyb8;Lyb-8;sialic acid-binding Ig-like lectin 2;siglec-2;T-cell surface antigen Leu-14
Description (eCommerce)
CD22 mediates B-cell B-cell interactions and is involved in the localization of B-cells in lymphoid tissues. CD22 binds sialylated glycoproteins including CD45. It is involved in B cell activation; negative regulation of the B cell receptor signaling pathway; and regulation of endocytosis. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P20273].
Description (Vector)
Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Gene ID
12483
Gene Name (eCommerce)
CD22 antigen
Gene Name (Vector)
CD22 antigen
Gene Symbol
Cd22
NCBI Taxonomy ID (eCommerce)
10090.0
ORF Size (aa)
2607
ORF Size (bp)
2607 bp
Protein Name (eCommerce)
B-cell receptor CD22
RefSeq ID
NM_009845
RefSeq Synonyms
NM_009845, NM_001043317, BC150807,
Research Areas
B Cell Receptor Signaling,Immunology,Signal Transduction
Research Areas (Faceted)
immunology,signal_transduction
Species
mouse
Target Sentence
CD22 mediates B-cell B-cell interactions and is involved in the localization of B-cells in lymphoid tissues. CD22 binds sialylated glycoproteins including CD45. It is involved in B cell activation; negative regulation of the B cell receptor signaling pathway; and regulation of endocytosis. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P20273].
UniGene ID
Mm.260994
UniProt ID (eCommerce)
P35329

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.