human RP1 Adenovirus
This is an Adenovirus expressing Human RP1.
ADV-232415
Ad-h-RP1
Ready-to-use Adenovirus expressing Human RP1 (retinitis pigmentosa 1 (autosomal dominant)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DCDC4A; ORP1
Description (Vector)
RP1 encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains, which bind microtubules and regulate microtubule polymerization. The encoded protein is a photoreceptor microtubule-associated protein and is required for correct stacking of outer segment disc. This protein and the RP1L1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. Because of its response to in vivo retinal oxygen levels, this protein was initially named ORP1 (oxygen-regulated protein-1). This protein was subsequently designated RP1 (retinitis pigmentosa 1) when it was found that mutations in this gene cause autosomal dominant retinitis pigmentosa. Mutations in this gene also cause autosomal recessive retinitis pigmentosa. Transcript variants resulted from an alternative promoter and alternative splicings have been found, which overlap the current reference sequence and has several exons upstream and downstream of the current reference sequence. However, the biological validity and full-length nature of some variants cannot be determined at this time.
Gene ID
6101
Gene Name (Vector)
retinitis pigmentosa 1 (autosomal dominant)
Gene Symbol
RP1
HGNC ID
HGNC:10263
ORF Size (aa)
6468
ORF Size (bp)
6468 bp
RefSeq ID
NM_006269
RefSeq Synonyms
NM_006269, BC172506, BC156507,
Species
human
UniGene ID
Hs.128938
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.