human SPTY2D1 Adenovirus

Name 
Ad-h-SPTY2D1
Cat No 
ADV-231642
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human MYCL.

ADV-231642
Ad-h-SPTY2D1

Ready-to-use Adenovirus expressing Human SPTY2D1 (SPT2 chromatin protein domain containing 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Protein KU002155; protein SPT2 homolog; Spt2; SPT2 domain-containing protein 1; SPT2, Suppressor of Ty, domain containing 1
Description (eCommerce)
SPT2, Suppressor of Ty (SPTY2D1) is a histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin (PubMed:26109053). It is required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription (PubMed:26109053). SPTY2D1 binds DNA and histones and promotes nucleosome assembly (in vitro) (PubMed:23378026, PubMed:26109053). It facilitates formation of tetrameric histone complexes containing histone H3 and H4 (PubMed:26109053). SPTY2D1 modulates RNA polymerase 1-mediated transcription (By similarity) and binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (PubMed:23378026) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q68D10].
Gene ID
144108
Gene Name (eCommerce)
SPT2 chromatin protein domain containing 1
Gene Name (Vector)
SPT2 chromatin protein domain containing 1
Gene Symbol
SPTY2D1
HGNC ID
HGNC:26818
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1056
ORF Size (bp)
1056 bp
Protein Name (eCommerce)
Protein SPT2 homolog
RefSeq ID
NM_194285
RefSeq Synonyms
NM_194285, BC056261,
Research Areas
Cell Biology
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
SPT2, Suppressor of Ty (SPTY2D1) is a histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin (PubMed:26109053). It is required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription (PubMed:26109053). SPTY2D1 binds DNA and histones and promotes nucleosome assembly (in vitro) (PubMed:23378026, PubMed:26109053). It facilitates formation of tetrameric histone complexes containing histone H3 and H4 (PubMed:26109053). SPTY2D1 modulates RNA polymerase 1-mediated transcription (By similarity) and binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (PubMed:23378026) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q68D10].
UniGene ID
Hs.719399
UniProt ID (eCommerce)
Q68D10

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.