human SNCA Adenovirus

Name
Ad-h-SNCA

Cat No
ADV-230206

Availability
4-5 weeks

This is an Adenovirus expressing Human SNCA.

ADV-230206

Ad-h-SNCA

Ready-to-use Adenovirus expressing Human SNCA (synuclein alpha). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

NACP; PARK1; PARK4; PD1

Description (Vector)

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.

Gene ID

6622

Gene Name (Vector)

synuclein alpha

Gene Symbol

SNCA

HGNC ID

HGNC:11138

ORF Size (aa)

423

ORF Size (bp)

423 bp

RefSeq ID

NM_000345

RefSeq Synonyms

NM_007308, NM_001146055, NM_001146054, NM_000345, BC108275, BC013293,

Species

human

UniGene ID

Hs.21374

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.