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human ZNF207 Adenovirus

Name 
Ad-h-ZNF207
Cat No 
ADV-228380
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human ZNF207.

ADV-228380
Ad-h-ZNF207

Ready-to-use Adenovirus expressing Human ZNF207 (zinc finger protein 207). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
BUB3-interacting and GLEBS motif-containing protein ZNF207; BuG; ZhBuG; ZZinc finger protein 207
Description (eCommerce)
ZNF207 is a kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks. Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 . According to another report, the stabilization is independent of the proteasome. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O43670].
Gene ID
7756
Gene Name (eCommerce)
zinc finger protein 207
Gene Name (Vector)
zinc finger protein 207
Gene Symbol
ZNF207
HGNC ID
HGNC:12998
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1188
ORF Size (bp)
1188 bp
Protein Name (eCommerce)
BUB3-interacting and GLEBS motif-containing protein ZNF207
RefSeq ID
NM_003457
RefSeq Synonyms
NM_003457, NM_001098507, NM_001032293, BC008023, BC002372,
Research Areas
Cell Cycle,Cell Division,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
ZNF207 is a kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks. Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 . According to another report, the stabilization is independent of the proteasome. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O43670].
UniGene ID
Hs.500775
UniProt ID (eCommerce)
O43670

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.