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human ZNF207 Over-expression AAV

Name 
AAV-h-ZNF207
Cat No 
AAV-228379
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human ZNF207.

AAV-228379
AAV-h-ZNF207

Ready-to-use AAV expressing Human ZNF207 (zinc finger protein 207). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BUB3-interacting and GLEBS motif-containing protein ZNF207; BuG; ZhBuG; ZZinc finger protein 207
Description (eCommerce)
ZNF207 is a kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks. Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 . According to another report, the stabilization is independent of the proteasome. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O43670].
Gene ID
7756
Gene Name (eCommerce)
zinc finger protein 207
Gene Name (Vector)
zinc finger protein 207
Gene Symbol
ZNF207
HGNC ID
HGNC:12998
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1188
ORF Size (bp)
1188 bp
Protein Name (eCommerce)
BUB3-interacting and GLEBS motif-containing protein ZNF207
RefSeq ID
NM_003457
RefSeq Synonyms
NM_003457, NM_001098507, NM_001032293, BC008023, BC002372,
Research Areas
Cell Cycle,Cell Division,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
ZNF207 is a kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks. Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 . According to another report, the stabilization is independent of the proteasome. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O43670].
UniGene ID
Hs.500775
UniProt ID (eCommerce)
O43670

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.