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human ZEB1 Adenovirus

Name 
Ad-h-ZEB1
Cat No 
ADV-228176
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human ZEB1.

ADV-228176
Ad-h-ZEB1

Ready-to-use Adenovirus expressing Human ZEB1 (zinc finger E-box binding homeobox 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
AREB6; BZP; delta-crystallin enhancer binding factor 1; DELTAEF1; FECD6; negative regulator of IL2; NIL2A; NIL-2-A zinc finger protein; posterior polymorphous corneal dystrophy 3; PPCD3; TCF8; TCF-8; Transcription factor 8; transcription factor 8 (represses interleukin 2 expression); ZFHEP; ZFHX1A; zinc finger E-box-binding homeobox 1; zinc finger homeodomain enhancer-binding protein
Description (eCommerce)
ZEB1 (zinc-finger E-box-binding homeobox 1), also known as TCF8 (transcription factor 8), is a delta-EF1/ZFH-1 C2H2-type zinc finger that bears seven C2H2-type zinc fingers and one homeobox DNA-binding domain. ZEB1 is a transcriptional repressor of interleukin-2 (IL-2). Mutations in the ZEB1 gene are associated with posterior corneal dystrophy type 3 (PPC3) a rare disorder characterized by metaplasia and overgrowth of corneal endothelial cells. ZEB1 appears to be critical to epithelial to mesenchymal transitions (EMT) during development and cancer metastasis. As a transcription factor involved in EMT, ZEB1 promotes EMT by repressing genes associated with the epithelial phenotype and activates genes associated with the mesenchymal phenotype.
Description (Vector)
ZEB1 encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.
Gene ID
6935
Gene Name (eCommerce)
zinc finger E-box binding homeobox 1
Gene Name (Vector)
zinc finger E-box binding homeobox 1
Gene Symbol
ZEB1
HGNC ID
HGNC:11642
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3378
ORF Size (bp)
3378 bp
Protein Name (eCommerce)
Zinc finger E-box-binding homeobox 1
RefSeq ID
NM_030751
RefSeq Synonyms
NM_030751, NM_001323678, NM_001323677, NM_001323676, NM_001323675, NM_001323674, NM_001323673, NM_001323672, NM_001323671, NM_001323666, NM_001323665, NM_001323664, NM_001323663, NM_001323662, NM_001323661, NM_001323660, NM_001323659, NM_001323658, NM_001323657, NM_001323656, NM_001323655, NM_001323654, NM_001323653, NM_001323652, NM_001323651, NM_001323650, NM_001323649, NM_001323648, NM_001323647, NM_001323646, NM_001323645, NM_001323644, NM_001323643, NM_001323642, NM_001323641, NM_001323638, NM_001174096, NM_001174095, NM_001174094, NM_001174093, NM_001128128, BC112392,
Research Areas
Cancer,Immunology,MicroRNAs in Cancer,Neurobiology,Neurodevelopment,Neurogenesis,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator,Transcriptional Misregulation in Cancer,Zinc-finger
Research Areas (Faceted)
cancer,genetics,signal_transduction,immunology,neurobiology,developmental_biology,signal_transduction,immunology,genetics,transcription_translation,cancer,cell_biology
Species
human
Target Sentence
ZEB1 (zinc-finger E-box-binding homeobox 1), also known as TCF8 (transcription factor 8), is a delta-EF1/ZFH-1 C2H2-type zinc finger that bears seven C2H2-type zinc fingers and one homeobox DNA-binding domain. ZEB1 is a transcriptional repressor of interleukin-2 (IL-2). Mutations in the ZEB1 gene are associated with posterior corneal dystrophy type 3 (PPC3) a rare disorder characterized by metaplasia and overgrowth of corneal endothelial cells. ZEB1 appears to be critical to epithelial to mesenchymal transitions (EMT) during development and cancer metastasis. As a transcription factor involved in EMT, ZEB1 promotes EMT by repressing genes associated with the epithelial phenotype and activates genes associated with the mesenchymal phenotype.
UniGene ID
Hs.124503
UniProt ID (eCommerce)
P37275

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.