human XRCC5 Adenovirus

Name 
Ad-h-XRCC5
Cat No 
ADV-227927
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human MBNL2.

ADV-227927
Ad-h-XRCC5

Ready-to-use Adenovirus expressing Human XRCC5 (X-ray repair cross complementing 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; KARP1; KARP-1; Ku autoantigen, 80kDa; KU80; Ku86; Ku86 autoantigen related protein 1; KUB2; lupus Ku autoantigen protein p86; NFIV; nuclear factor IV; thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); X-ray repair cross-complementing protein 5
Description (eCommerce)
Ku80 is the 80 kDa subunit of the lupus Ku autoantigen. The lupus Ku autoantigen was identified in individuals with systemic lupus erythematosus (SLE) and related disorders. The Ku antigen is a heterodimer of Ku70 and Ku80. The Ku70/Ku80 complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P13010].
Description (Vector)
XRCC5 is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
Gene ID
7520
Gene Name (eCommerce)
X-ray repair cross complementing 5
Gene Name (Vector)
X-ray repair cross complementing 5
Gene Symbol
XRCC5
HGNC ID
HGNC:12833
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2199
ORF Size (bp)
2199 bp
Protein Name (eCommerce)
X-ray repair cross-complementing protein 5
RefSeq ID
NM_021141
RefSeq Synonyms
NM_021141, BC095442, BC019027,
Research Areas
Aging,Apoptosis,DNA Damage/Repair,Helicase Activity,Host-Virus Interactions,Immunology,Innate Immunity,Neurobiology,Neurodevelopment,Neurogenesis,Signal Transduction,Telomeric Maintenance,Transcription Factor/Regulator
Research Areas (Faceted)
signal_transduction,cell_biology,genetics,transcription_translation,cell_biology,infectious_disease,immunology,neurobiology,developmental_biology,genetics,transcription_translation
Species
human
Target Sentence
Ku80 is the 80 kDa subunit of the lupus Ku autoantigen. The lupus Ku autoantigen was identified in individuals with systemic lupus erythematosus (SLE) and related disorders. The Ku antigen is a heterodimer of Ku70 and Ku80. The Ku70/Ku80 complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P13010].
UniGene ID
Hs.388739
UniProt ID (eCommerce)
P13010

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.