human WHSC1 Adenovirus

Name 
Ad-h-WHSC1
Cat No 
ADV-227781
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human WHSC1.

ADV-227781
Ad-h-WHSC1

Ready-to-use Adenovirus expressing Human NSD2 (nuclear receptor binding SET domain protein 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
histone-lysine N-methyltransferase NSD2; IL5 promoter REII region-binding protein; KMT3F; KMT3G; MMSET; multiple myeloma SET domain containing protein type III; Multiple myeloma SET domain-containing protein; nuclear SET domain-containing protein 2; probable histone-lysine N-methyltransferase NSD2; Protein trithorax-5; REIIBP; trithorax/ash1-related protein 5; TRX5; WHS; WHSC1; Wolf-Hirschhorn syndrome candidate 1; Wolf-Hirschhorn syndrome candidate 1 protein
Description (eCommerce)
MMSET (multiple myeloma SET domain-containing protein) or NSD2 (nuclear SET-domain containing protein 2) is the product of the Wolf-Hirschhorn syndrome candidate 1 (WHSC1) gene. MMSET is a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development and is a probable histone methyltransferase. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4 [taken from NCBI Entrez Gene (Gene ID: 7468].
Description (Vector)
WHSC1 encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. WHSC1 maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences.
Gene ID
7468
Gene Name (eCommerce)
nuclear receptor binding SET domain protein 2
Gene Name (Vector)
nuclear receptor binding SET domain protein 2
Gene Symbol
NSD2
HGNC ID
HGNC:12766
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4098
ORF Size (bp)
4098 bp
Protein Name (eCommerce)
Histone-lysine N-methyltransferase NSD2
RefSeq ID
NM_007331
RefSeq Synonyms
NM_133335, NM_133334, NM_133331, NM_133330, NM_007331, NM_001042424, BC166668, BC152412,
Research Areas
Cancer,Cardiology,Cell Biology,Histone Modification,Metabolism/Metabolic Process,Methyltransferase,Neurobiology,Transcription Factor/Regulator,Transcriptional Misregulation in Cancer,Translational Control,Zinc-finger
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,metabolism,neurobiology,transcription_translation
Species
human
Target Sentence
MMSET (multiple myeloma SET domain-containing protein) or NSD2 (nuclear SET-domain containing protein 2) is the product of the Wolf-Hirschhorn syndrome candidate 1 (WHSC1) gene. MMSET is a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development and is a probable histone methyltransferase. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4 [taken from NCBI Entrez Gene (Gene ID: 7468].
UniGene ID
Hs.113876
UniProt ID (eCommerce)
O96028

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.