human UNG Adenovirus

Name 
Ad-h-UNG
Cat No 
ADV-227212
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human LYG1.

ADV-227212
Ad-h-UNG

Ready-to-use Adenovirus expressing Human UNG (uracil DNA glycosylase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
DGU; HIGM4; HIGM5; UDG; UNG1; UNG15; UNG2; uracil-DNA glycosylase; uracil-DNA glycosylase 1, uracil-DNA glycosylase 2
Description (eCommerce)
Uracil-DNA glycosylase functions as an enzyme that excises uracil residues from DNA. Uracil residues in DNA can arise as a result of misincorporation of dUMP residues by DNA polymerase or from the deamination of cytosine. Defects in UNG are a cause of immunodeficiency with hyper-IgM type 5 syndrome (HIGM5) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P13051].
Description (Vector)
UNG encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases.
Gene ID
7374
Gene Name (eCommerce)
uracil DNA glycosylase
Gene Name (Vector)
uracil DNA glycosylase
Gene Symbol
UNG
HGNC ID
HGNC:12572
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
915
Protein Name (eCommerce)
Uracil-DNA glycosylase
RefSeq ID
NM_003362
RefSeq Synonyms
NM_080911, NM_003362, BC050634, BC015205,
Research Areas
DNA Damage/Repair,Host-Virus Interactions,Immunology,Mitochondrion
Research Areas (Faceted)
cell_biology,genetics,immunology,infectious_disease,transcription_translation
Species
human
Target Sentence
Uracil-DNA glycosylase functions as an enzyme that excises uracil residues from DNA. Uracil residues in DNA can arise as a result of misincorporation of dUMP residues by DNA polymerase or from the deamination of cytosine. Defects in UNG are a cause of immunodeficiency with hyper-IgM type 5 syndrome (HIGM5) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P13051].
UniGene ID
Hs.191334
UniProt ID (eCommerce)
P13051

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.