human TP63 Adenovirus
This is an Adenovirus expressing Human TP63.
ADV-226240
Ad-h-TP63
Ready-to-use Adenovirus expressing Human TP63 (tumor protein p63). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AIS; amplified in squamous cell carcinoma; B(p51A); B(p51B); chronic ulcerative stomatitis protein; CUSP; EEC3; keratinocyte transcription factor KET; KET; LMS; NBP; OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4; TP53CP; TP53L; TP63; TP73L; transformation-related protein 63; tumor protein 63; tumor protein p53-competing protein; Tumor protein p73-like
Description (eCommerce)
Tumor protein p63 is a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. P63 is an extremely sensitive marker of lung squamous cell carcinoma, but it suffers from low specificity due to its reactivity in a substantial proportion of lung adenocarcinomas and other tumor types. P40 is a splice isoform of p63 known as DeltaNp63 and has been demonstrated to be highly specific for squamous/basal cells making it is markedly superior to p63 in specificity [adapted from NCBI Entrez Gene (Gene ID: 8626)].
Description (Vector)
TP63 encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.
Gene ID
8626
Gene Name (eCommerce)
tumor protein p63
Gene Name (Vector)
tumor protein p63
Gene Symbol
TP63
HGNC ID
HGNC:15979
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2043
ORF Size (bp)
2043 bp
Protein Name (eCommerce)
Tumor protein 63
RefSeq ID
NM_003722
RefSeq Synonyms
NM_003722, NM_001329964, NM_001329150, NM_001329149, NM_001329148, NM_001329146, NM_001329145, NM_001329144, NM_001114982, NM_001114981, NM_001114980, NM_001114979, NM_001114978, BC039815,
Research Areas
Aging,Apoptosis,Cancer,Cell Cycle,DNA Damage/Repair,Golgi Apparatus,Neurobiology,Neurodevelopment,Notch Signaling,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation,cell_biology,neurobiology,developmental_biology,signal_transduction,genetics,transcription_translation
Species
human
Target Sentence
Tumor protein p63 is a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. P63 is an extremely sensitive marker of lung squamous cell carcinoma, but it suffers from low specificity due to its reactivity in a substantial proportion of lung adenocarcinomas and other tumor types. P40 is a splice isoform of p63 known as DeltaNp63 and has been demonstrated to be highly specific for squamous/basal cells making it is markedly superior to p63 in specificity [adapted from NCBI Entrez Gene (Gene ID: 8626)].
UniGene ID
Hs.137569
UniProt ID (eCommerce)
Q9H3D4
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.