human TP53BP1 Adenovirus
This is an Adenovirus expressing Human TP53BP1.
ADV-226230
Ad-h-TP53BP1
Ready-to-use Adenovirus expressing Human TP53BP1 (tumor protein p53 binding protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
53BP1; p202; p53-binding protein 1; p53BP1; TDRD30; TP53-binding protein 1; tumor protein 53-binding protein, 1; tumor suppressor p53-binding protein 1
Description (eCommerce)
53BP1 (p53 Binding Protein 1) is an early participant in the cellular response to DNA double-strand breaks. 53BP1 functions in a redundant role in phosphorylation of the downstream checkpoint effector proteins Brca1 and Chk2 but was required for the formation of Brca1 foci in a hierarchical branched pathway for the recruitment of repair and signaling proteins to sites of DNA damage.
Gene ID
7158
Gene Name (eCommerce)
tumor protein p53 binding protein 1
Gene Name (Vector)
tumor protein p53 binding protein 1
Gene Symbol
TP53BP1
HGNC ID
HGNC:11999
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5919
ORF Size (bp)
5919 bp
Protein Name (eCommerce)
Tumor suppressor p53-binding protein 1
RefSeq ID
NM_005657
RefSeq Synonyms
NM_005657, NM_001141980, NM_001141979, BC112161,
Research Areas
Cell Cycle,DNA Damage/Repair,Homologous Recombination,Phospho-specific,Replication,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
53BP1 (p53 Binding Protein 1) is an early participant in the cellular response to DNA double-strand breaks. 53BP1 functions in a redundant role in phosphorylation of the downstream checkpoint effector proteins Brca1 and Chk2 but was required for the formation of Brca1 foci in a hierarchical branched pathway for the recruitment of repair and signaling proteins to sites of DNA damage.
UniGene ID
Hs.440968
UniProt ID (eCommerce)
Q12888
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.