human TOP2B Adenovirus
This is an Adenovirus expressing Human TOP2B.
ADV-226204
Ad-h-TOP2B
Ready-to-use Adenovirus expressing Human TOP2B (topoisomerase (DNA) II beta). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
antigen MLAA-44; DNA topoisomerase 2-beta; DNA topoisomerase II, 180 kD; DNA topoisomerase II, beta isozyme; top2beta; TOPIIB; topo II beta; topoisomerase (DNA) II beta 180kDa; topoisomerase II beta; topoisomerase IIb; U937 associated antigen
Description (eCommerce)
Topoisomerases regulate topological states of DNA and are divided into type I and type II enzymes. Type II topoisomerases make double stranded breaks in DNA and allow the passage of another duplex DNA across the break to achieve unknotting of entangled DNA. Topo II beta is one of two described isoforms that are likely products of a gene duplication event. TopoII beta is also described to be involved in chromosome condensation, chromatid separation, and the relief of supercoil stress.
Description (Vector)
TOP2B encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants; however, the second variant has not yet been fully described.
Gene ID
7155
Gene Name (eCommerce)
DNA topoisomerase II beta
Gene Name (Vector)
topoisomerase (DNA) II beta
Gene Symbol
TOP2B
HGNC ID
HGNC:11990
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4863
ORF Size (bp)
4863 bp
Protein Name (eCommerce)
DNA topoisomerase 2-beta
RefSeq ID
NM_001068
RefSeq Synonyms
NM_001330700, NM_001068, BC157118, BC156330,
Research Areas
Axonogenesis,Brain Development,Cardiology,Cardiovascular,Cell Cycle,Chromatin Remodeling,DNA Replication,Histone Modification,Neurobiology,Neurodevelopment
Research Areas (Faceted)
neurobiology,developmental_biology,neurobiology,developmental_biology,cardiovascular,cell_biology,cell_cycle,genetics,transcription_translation,neurobiology,developmental_biology
Species
human
Target Sentence
Topoisomerases regulate topological states of DNA and are divided into type I and type II enzymes. Type II topoisomerases make double stranded breaks in DNA and allow the passage of another duplex DNA across the break to achieve unknotting of entangled DNA. Topo II beta is one of two described isoforms that are likely products of a gene duplication event. TopoII beta is also described to be involved in chromosome condensation, chromatid separation, and the relief of supercoil stress.
UniGene ID
Hs.475733
UniProt ID (eCommerce)
Q02880
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.