Promotional banner reading 'FALL SAVINGS' with expiry date August 31 on an orange background; features a group of people with orange stacked blocks on the right and discounts for services and catalog products.

human TNNI2 Adenovirus

Name 
Ad-h-TNNI2
Cat No 
ADV-226131
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human TNNI2.

ADV-226131
Ad-h-TNNI2

Ready-to-use Adenovirus expressing Human TNNI2 (troponin I2, fast skeletal type). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
AMCD2B;DA2B;FSSV;fsTnI;troponin I fast twitch 2;troponin I type 2 (skeletal, fast);troponin I, fast skeletal muscle;troponin I, fast-twitch isoform;troponin I, fast-twitch skeletal muscle isoform;troponin I, skeletal, fast
Description (eCommerce)
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. The Troponin I subfamily contains three genes: Troponin I-skeletal-fast-twitch, Troponin I-skeletal-slow-twitch, and Troponin I-cardiac. Troponin I-cardiac is exclusively expressed in cardiac muscle tissues. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P19429].
Description (Vector)
TNNI2 encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene.
Gene ID
7136
Gene Name (eCommerce)
troponin I2, fast skeletal type
Gene Name (Vector)
troponin I2, fast skeletal type
Gene Symbol
TNNI2
HGNC ID
HGNC:11946
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
549
Protein Name (eCommerce)
Troponin I, fast skeletal muscle
RefSeq ID
NM_003282
RefSeq Synonyms
NM_003282, NM_001145841, NM_001145829, BC032148,
Research Areas
Cell Biology, Cytoskeleton
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. The Troponin I subfamily contains three genes: Troponin I-skeletal-fast-twitch, Troponin I-skeletal-slow-twitch, and Troponin I-cardiac. Troponin I-cardiac is exclusively expressed in cardiac muscle tissues. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P19429].
UniGene ID
Hs.523403
UniProt ID (eCommerce)
P48788

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.