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human TJP3 Adenovirus

Name 
Ad-h-TJP3
Cat No 
ADV-225547
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human TJP3.

ADV-225547
Ad-h-TJP3

Ready-to-use Adenovirus expressing Human TJP3 (tight junction protein 3 (zona occludens 3)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Tight junction protein 3; tight junction protein 3 (zona occludens 3); tight junction protein ZO-3; ZO3; ZO-3; zona occludens protein 3; zonula occludens protein 3
Description (eCommerce)
Tight junction protein 3 (TJP3) is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. TJP3 plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis [taken from NCBI Entrez Gene (Gene ID: 27134)].
Description (Vector)
TJP3 is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. TJP3 plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1.
Gene ID
27134
Gene Name (eCommerce)
tight junction protein 3
Gene Name (Vector)
tight junction protein 3 (zona occludens 3)
Gene Symbol
TJP3
HGNC ID
HGNC:11829
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2817
ORF Size (bp)
2817 bp
Protein Name (eCommerce)
Tight junction protein ZO-3
RefSeq ID
NM_014428
RefSeq Synonyms
NM_014428, NM_001267561, NM_001267560, BC108906,
Research Areas
Cell Biology,Translational Control
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
Tight junction protein 3 (TJP3) is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. TJP3 plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis [taken from NCBI Entrez Gene (Gene ID: 27134)].
UniGene ID
Hs.25527
UniProt ID (eCommerce)
O95049

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.