human STK4 Adenovirus
This is an Adenovirus expressing Human KLF2.
ADV-224602
Ad-h-STK4
Ready-to-use Adenovirus expressing Human STK4 (serine/threonine kinase 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
kinase responsive to stress 2; KRS2; mammalian STE20-like protein kinase 1; mammalian sterile 20-like 1; MST1; MST-1; serine/threonine-protein kinase 4; serine/threonine-protein kinase Krs-2; STE20-like kinase MST1; YSK3
Description (eCommerce)
MST1 is a member of the sterile 20 (Ste20)-like kinase family that acts upstream of mitogen-activated protein kinase (MAPK) pathways and regulates c-Jun N-terminal kinase (JNK), p38 and extracellular signal-regulated kinase (ERK). Ste20-like kinases are involved in a variety of cellular processes which include gene transcription, stress responses, cytoskeletal organization and apoptosis. MST1 can phosphorylate myelin basic protein and FOXO3. MST1 has been identified as a substrate of caspase and is required to mediate apoptosis in response to various apoptotic stimuli.
Description (Vector)
STK4 is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.
Gene ID
6789
Gene Name (eCommerce)
serine/threonine kinase 4
Gene Name (Vector)
serine/threonine kinase 4
Gene Symbol
STK4
HGNC ID
HGNC:11408
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1464
ORF Size (bp)
1464 bp
Protein Name (eCommerce)
Serine/threonine-protein kinase 4
RefSeq ID
NM_006282
RefSeq Synonyms
NM_006282, BC093768, BC005231,
Research Areas
Apoptosis,Cancer,Cardiac Development,Cardiovascular,Hippo Signaling,Immunology,Kinase/Phosphatase,Lung Cancer,MAPK Signaling,Neurobiology,Neurodevelopment,Signal Transduction,T-cell Receptor Signaling,Transcription Factor/Regulator,Wnt Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,immunology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
MST1 is a member of the sterile 20 (Ste20)-like kinase family that acts upstream of mitogen-activated protein kinase (MAPK) pathways and regulates c-Jun N-terminal kinase (JNK), p38 and extracellular signal-regulated kinase (ERK). Ste20-like kinases are involved in a variety of cellular processes which include gene transcription, stress responses, cytoskeletal organization and apoptosis. MST1 can phosphorylate myelin basic protein and FOXO3. MST1 has been identified as a substrate of caspase and is required to mediate apoptosis in response to various apoptotic stimuli.
UniGene ID
Hs.472838
UniProt ID (eCommerce)
Q13043
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.