human STAU1 Adenovirus

Name
Ad-h-STAU1

Cat No
ADV-224545

Availability
4-5 weeks

This is an Adenovirus expressing Human STAU1.

ADV-224545

Ad-h-STAU1

Ready-to-use Adenovirus expressing Human STAU1 (staufen double-stranded RNA binding protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

double-stranded RNA-binding protein Staufen homolog 1; PPP1R150; protein phosphatase 1, regulatory subunit 150; STAU; staufen, RNA binding protein, homolog 1

Description (eCommerce)

Staufen1 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen1 contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. Staufen1 has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation [taken from NCBI Entrez Gene (Gene ID: 67803)].

Description (Vector)

Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR.

Gene ID

6780

Gene Name (eCommerce)

staufen double-stranded RNA binding protein 1

Gene Name (Vector)

staufen double-stranded RNA binding protein 1

Gene Symbol

STAU1

HGNC ID

HGNC:11370

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1491

ORF Size (bp)

1491 bp

Protein Name (eCommerce)

Double-stranded RNA-binding protein Staufen homolog 1

RefSeq ID

NM_004602

RefSeq Synonyms

NM_017454, NM_017453, NM_017452, NM_004602, NM_001322933, NM_001322932, NM_001322931, NM_001322930, NM_001322929, NM_001322928, NM_001322927, NM_001319135, NM_001319134, NM_001037328, BC095397, BC050432,

Research Areas

Kinase/Phosphatase,RNA Binding,RNA Processing

Research Areas (Faceted)

cell_biology,genetics,signal_transduction,transcription_translation

Species

human

Target Sentence

UniGene ID

Hs.596704

UniProt ID (eCommerce)

O95793

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.