human STAM2 Adenovirus

Name 
Ad-h-STAM2
Cat No 
ADV-224505
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human KIN.

ADV-224505
Ad-h-STAM2

Ready-to-use Adenovirus expressing Human STAM2 (signal transducing adaptor molecule 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Hbp; Hrs-binding protein; HSE1 homolog; signal transducing adapter molecule 2; signal transducing adaptor molecule (SH3 domain and ITAM motif) 2; STAM-2; STAM2A; STAM2B; STAM-like protein containing SH3 and ITAM domains 2
Description (eCommerce)
STAM2 is involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. It may also play a role in T-cell development [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O75886].
Description (Vector)
STAM2 is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation.
Gene ID
10254
Gene Name (eCommerce)
signal transducing adaptor molecule 2
Gene Name (Vector)
signal transducing adaptor molecule 2
Gene Symbol
STAM2
HGNC ID
HGNC:11358
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1578
ORF Size (bp)
1578 bp
Protein Name (eCommerce)
Signal transducing adapter molecule 2
RefSeq ID
NM_005843
RefSeq Synonyms
NM_005843, BC028740,
Research Areas
Cancer,EGFR Signaling,EGFR Signaling in Cancer,Immunology,Interleukin Signaling,JAK-STAT Signaling,Signal Transduction,T-cell Receptor Signaling
Research Areas (Faceted)
cancer,immunology,signal_transduction
Species
human
Target Sentence
STAM2 is involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. It may also play a role in T-cell development [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O75886].
UniGene ID
Hs.17200
UniProt ID (eCommerce)
O75886

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.