human SRRT Adenovirus

Name 
Ad-h-SRRT
Cat No 
ADV-224368
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human SRRT.

ADV-224368
Ad-h-SRRT

Ready-to-use Adenovirus expressing Human SRRT (serrate, RNA effector molecule). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ARS2; arsenate resistance protein 2; arsenate resistance protein ARS2; arsenite resistance protein; arsenite-resistance protein 2; ASR2; serrate; serrate RNA effector molecule homolog
Description (eCommerce)
Arsenate resistance protein 2 (ARS2) acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. ARS2 contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. ARS2 does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, it is necessary and sufficient to promote neural stem cell self-renewa and does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BXP5].
Gene ID
51593
Gene Name (eCommerce)
serrate, RNA effector molecule
Gene Name (Vector)
serrate, RNA effector molecule
Gene Symbol
SRRT
HGNC ID
HGNC:24101
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2616
ORF Size (bp)
2616 bp
Protein Name (eCommerce)
Serrate RNA effector molecule homolog
RefSeq ID
NM_015908
RefSeq Synonyms
NM_015908, NM_001128854, NM_001128853, NM_001128852, BC109117,
Research Areas
Neurobiology,RNA Processing,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,neurobiology,transcription_translation
Species
human
Target Sentence
Arsenate resistance protein 2 (ARS2) acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. ARS2 contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. ARS2 does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, it is necessary and sufficient to promote neural stem cell self-renewa and does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BXP5].
UniGene ID
Hs.111801
UniProt ID (eCommerce)
Q9BXP5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.