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human SMEK2 Adenovirus

Name 
Ad-h-SMEK2
Cat No 
ADV-223749
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human SMEK2.

ADV-223749
Ad-h-SMEK2

Ready-to-use Adenovirus expressing Human PPP4R3B (protein phosphatase 4 regulatory subunit 3B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
FLFL2; PP4R3B; PSY2; serine/threonine-protein phosphatase 4 regulatory subunit 3B; SMEK homolog 2; SMEK homolog 2, suppressor of mek1; SMEK2; smk1
Description (eCommerce)
PPP4R3 is a binding partner of the PPP4C catalytic subunit of the PP4 serine/threonine protein phosphatase. PPP4C is structurally related to PP2AC but does not associate with the same regulatory subunits. PPP4C associates with either the PPP4R1 or PPP4R2 regulatory subunit. In addition to PPP4R1 and PPP4R2, PPP4R3 has also been identified as a regulator of PPP4C function. PP4R3 functions with PP4C in the control of recovery from DNA damage. PP4R3 may function by targeting PPP4 to sites of DNA damage via an interaction with Rad53 (CHK2). PP4R3 is the human homolog of the Dictylostelium SMEK (suppressor of MEK). SMEK has been shown to be involved in cell polarization and chemotaxis via an involvement in the MEK1/ERK1 signaling pathway. SMEK also functions by controlling PPP4C localization to nucleus.
Gene ID
57223
Gene Name (eCommerce)
protein phosphatase 4 regulatory subunit 3B
Gene Name (Vector)
protein phosphatase 4 regulatory subunit 3B
Gene Symbol
PPP4R3B
HGNC ID
HGNC:29267
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2295
ORF Size (bp)
2295 bp
Protein Name (eCommerce)
Serine/threonine-protein phosphatase 4 regulatory subunit 3B
RefSeq ID
NM_020463
RefSeq Synonyms
NM_020463, NM_001282850, NM_001122964, BC060855, BC006215,
Research Areas
Cancer,Cell Biology,Cytoskeleton,Signal Transduction
Research Areas (Faceted)
cancer,signal_transduction,cell_biology
Species
human
Target Sentence
PPP4R3 is a binding partner of the PPP4C catalytic subunit of the PP4 serine/threonine protein phosphatase. PPP4C is structurally related to PP2AC but does not associate with the same regulatory subunits. PPP4C associates with either the PPP4R1 or PPP4R2 regulatory subunit. In addition to PPP4R1 and PPP4R2, PPP4R3 has also been identified as a regulator of PPP4C function. PP4R3 functions with PP4C in the control of recovery from DNA damage. PP4R3 may function by targeting PPP4 to sites of DNA damage via an interaction with Rad53 (CHK2). PP4R3 is the human homolog of the Dictylostelium SMEK (suppressor of MEK). SMEK has been shown to be involved in cell polarization and chemotaxis via an involvement in the MEK1/ERK1 signaling pathway. SMEK also functions by controlling PPP4C localization to nucleus.
UniGene ID
Hs.516182
UniProt ID (eCommerce)
Q5MIZ7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.