human RBM28 Adenovirus

Name 
Ad-h-RBM28
Cat No 
ADV-220867
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human HIST1H2AH.

ADV-220867
Ad-h-RBM28

Ready-to-use Adenovirus expressing Human RBM28 (RNA binding motif protein 28). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
2810480G15Rik; ANES; RNA-binding motif protein 28; RNA-binding protein 28
Description (eCommerce)
RNA-binding protein 28 (RBM28) is a nucleolar component of the spliceosomal ribonucleoprotein complexes that interacts with U1, U2, U4, U5, and U6 spliceosomal small nuclear RNAs (snRNAs). Defects in RBM28 are the cause of alopecia neurologic defects and endocrinopathy syndrome (ANES) [MIM:612079]. Affected individuals have hair loss of variable severity, ranging from complete alopecia to near-normal scalp hair with absence of body hair [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NW13].
Description (Vector)
RBM28 is a specific nucleolar component of the spliceosomal small nuclear ribonucleoprotein (snRNP)complexes . It specifically associates with U1, U2, U4, U5, and U6 small nuclear RNAs (snRNAs), possibly coordinating their transition through the nucleolus. Mutation in this gene causes alopecia, progressive neurological defects, and endocrinopathy (ANE syndrome), a pleiotropic and clinically heterogeneous disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
55131
Gene Name (eCommerce)
RNA binding motif protein 28
Gene Name (Vector)
RNA binding motif protein 28
Gene Symbol
RBM28
HGNC ID
HGNC:21863
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2280
ORF Size (bp)
2280 bp
Protein Name (eCommerce)
RNA-binding protein 28
RefSeq ID
NM_018077
RefSeq Synonyms
NM_018077, NM_001166135, BC013889,
Research Areas
Gene Expression,Golgi Apparatus,mRNA Processing,mRNA Splicing,Neurobiology,RNA Binding,RNA Processing,Spliceosome
Research Areas (Faceted)
genetics,transcription_translation,cell_biology,genetics,neurobiology
Species
human
Target Sentence
RNA-binding protein 28 (RBM28) is a nucleolar component of the spliceosomal ribonucleoprotein complexes that interacts with U1, U2, U4, U5, and U6 spliceosomal small nuclear RNAs (snRNAs). Defects in RBM28 are the cause of alopecia neurologic defects and endocrinopathy syndrome (ANES) [MIM:612079]. Affected individuals have hair loss of variable severity, ranging from complete alopecia to near-normal scalp hair with absence of body hair [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NW13].
UniGene ID
Hs.274263
UniProt ID (eCommerce)
Q9NW13

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.