human RAPGEF6 Adenovirus

Name
Ad-h-RAPGEF6

Cat No
ADV-220740

Availability
4-5 weeks

This is an Adenovirus expressing Human RAPGEF6.

ADV-220740

Ad-h-RAPGEF6

Ready-to-use Adenovirus expressing Human RAPGEF6 (Rap guanine nucleotide exchange factor 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

KIA001LB; PDZ domain containing guanine nucleotide exchange factor (GEF) 2; PDZ domain-containing guanine nucleotide exchange factor 2; PDZ domain-containing guanine nucleotide exchange factor I; PDZGEF2; PDZ-GEF2; RAGEF2; RA-GEF-2; Rap guanine nucleotide exchange factor (GEF) 6; rap guanine nucleotide exchange factor 6

Description (eCommerce)

PDZ-GEF2 is a guanine nucleotide exchange factor (GEF) for Rap GTPases. It contains one PDZ-signaling domain, a Ras-association (RA) domain, and a region related to a cyclic nucleotide binding domain (RCBD). PDZ-GEF1 functions to catalyze the exchange of GDP for GTP and activate Rap1A, Rap1B, and Rap2B GTPase activity. PDZ-GEF2 has been shown to activate Rap1A and Rap1B to promote the maturation of cell-cell adherens junctions.

Gene ID

51735

Gene Name (eCommerce)

Rap guanine nucleotide exchange factor 6

Gene Name (Vector)

Rap guanine nucleotide exchange factor 6

Gene Symbol

RAPGEF6

HGNC ID

HGNC:20655

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2484

ORF Size (bp)

2484 bp

Protein Name (eCommerce)

Rap guanine nucleotide exchange factor 6

RefSeq ID

NM_016340

RefSeq Synonyms

NM_016340, NM_001164390, NM_001164389, NM_001164388, NM_001164387, NM_001164386, BC144627, BC142964, BC140820, BC133703,

Research Areas

Neurobiology,Signal Transduction

Research Areas (Faceted)

signal_transduction,neurobiology

Species

human

Target Sentence

PDZ-GEF2 is a guanine nucleotide exchange factor (GEF) for Rap GTPases. It contains one PDZ-signaling domain, a Ras-association (RA) domain, and a region related to a cyclic nucleotide binding domain (RCBD). PDZ-GEF1 functions to catalyze the exchange of GDP for GTP and activate Rap1A, Rap1B, and Rap2B GTPase activity. PDZ-GEF2 has been shown to activate Rap1A and Rap1B to promote the maturation of cell-cell adherens junctions.

UniGene ID

Hs.483329

UniProt ID (eCommerce)

Q8TEU7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.