human RAD51C Adenovirus

Name 
Ad-h-RAD51C
Cat No 
ADV-220646
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human HEPN1.

ADV-220646
Ad-h-RAD51C

Ready-to-use Adenovirus expressing Human RAD51C (RAD51 paralog C). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
BROVCA3; DNA repair protein RAD51 homolog 3; FANCO; R51H3; RAD51 homolog C; RAD51L2; RAD51-like protein 2; yeast RAD51 homolog 3
Description (eCommerce)
RAD51C (RAD51 homolog C) is involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. RAD51C is part of the BCDX2 complex. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA, and nicks in duplex DNA [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O43502].
Description (Vector)
RAD51C is a member of the RAD51 family of related genes, which encode strand-transfer proteins thought to be involved in recombinational repair of damaged DNA and in meiotic recombination. RAD51C product interacts with two other DNA repair proteins, encoded by RAD51B and XRCC3, but not with itself. The protein copurifies with XRCC3 protein in a complex, reflecting their endogenous association and suggesting a cooperative role during recombinational repair. RAD51C is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing has been observed for this gene and two variants encoding different isoforms have been identified.
Gene ID
5889
Gene Name (eCommerce)
RAD51 paralog C
Gene Name (Vector)
RAD51 paralog C
Gene Symbol
RAD51C
HGNC ID
HGNC:9820
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1131
ORF Size (bp)
1131 bp
Protein Name (eCommerce)
DNA repair protein RAD51 homolog 3
RefSeq ID
NM_002876
RefSeq Synonyms
NM_058216, NM_002876, BC107753, BC000667,
Research Areas
Cell Cycle,DNA Damage/Repair,Fanconi anemia,Homologous Recombination,Meiosis,Mitochondrion,Spermatogenesis
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,transcription_translation
Species
human
Target Sentence
RAD51C (RAD51 homolog C) is involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. RAD51C is part of the BCDX2 complex. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA, and nicks in duplex DNA [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O43502].
UniGene ID
Hs.412587
UniProt ID (eCommerce)
O43502

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.