human PVR Adenovirus
This is an Adenovirus expressing Human HBEGF.
ADV-220415
Ad-h-PVR
Ready-to-use Adenovirus expressing Human PVR (poliovirus receptor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD antigen CD155; CD155; HVED; NECL5; Necl-5; nectin-like protein 5; poliovirus receptor; PVS; TAGE4
Description (eCommerce)
PVR/CD155 is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. It mediates NK cell adhesion and triggers NK cell effector functions. PVR/CD155 binds two different NK cell receptors: CD96 and CD226, and these interactions accumulate at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. PVR/Cd155 also promotes NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. PVR/CD155 also plays a role in mediating tumor cell invasion and migration. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P15151].
Description (Vector)
PVR is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
5817
Gene Name (eCommerce)
poliovirus receptor
Gene Name (Vector)
poliovirus receptor
Gene Symbol
PVR
HGNC ID
HGNC:9705
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1254
ORF Size (bp)
1254 bp
Protein Name (eCommerce)
Poliovirus receptor
RefSeq ID
NM_006505
RefSeq Synonyms
NM_006505, NM_001135770, NM_001135769, NM_001135768, BC015542,
Research Areas
Host-Virus Interactions,Immunology,Signal Transduction
Research Areas (Faceted)
signal_transduction,infectious_disease,immunology
Species
human
Target Sentence
PVR/CD155 is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. It mediates NK cell adhesion and triggers NK cell effector functions. PVR/CD155 binds two different NK cell receptors: CD96 and CD226, and these interactions accumulate at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. PVR/Cd155 also promotes NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. PVR/CD155 also plays a role in mediating tumor cell invasion and migration. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P15151].
UniGene ID
Hs.171844
UniProt ID (eCommerce)
P15151
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.