human PTAFR Adenovirus

Name
Ad-h-PTAFR

Cat No
ADV-220203

Availability
4-5 weeks

This is an Adenovirus expressing Human PTAFR.

ADV-220203

Ad-h-PTAFR

Ready-to-use Adenovirus expressing Human PTAFR (platelet activating factor receptor). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

PAFR

Description (Vector)

PTAFR encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.

Gene ID

5724

Gene Name (Vector)

platelet activating factor receptor

Gene Symbol

PTAFR

HGNC ID

HGNC:9582

ORF Size (aa)

1029

ORF Size (bp)

1029 bp

RefSeq ID

NM_000952

RefSeq Synonyms

NM_001164723, NM_001164722, NM_001164721, NM_000952, BC063000, BC013816,

Species

human

UniGene ID

Hs.709174

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.