human PSME2 Adenovirus
This is an Adenovirus expressing Human PSME2.
ADV-220177
Ad-h-PSME2
Ready-to-use Adenovirus expressing Human PSME2 (proteasome activator subunit 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
PA28B; PA28beta; REGbeta
Description (Vector)
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13.
Gene ID
5721
Gene Name (Vector)
proteasome activator subunit 2
Gene Symbol
PSME2
HGNC ID
HGNC:9569
ORF Size (aa)
720
RefSeq ID
NM_002818
RefSeq Synonyms
NM_002818, BC072025, BC019885, BC004368,
Species
human
UniGene ID
Hs.512410
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.