human PRKCI Adenovirus
This is an Adenovirus expressing Human PRKCI.
ADV-219866
Ad-h-PRKCI
Ready-to-use Adenovirus expressing Human PRKCI (protein kinase C iota). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DXS1179E; nPKC-iota; PKCI
Description (Vector)
PRKCI encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.
Gene ID
5584
Gene Name (Vector)
protein kinase C iota
Gene Symbol
PRKCI
HGNC ID
HGNC:9404
ORF Size (aa)
1764
ORF Size (bp)
1764 bp
RefSeq ID
NM_002740
RefSeq Synonyms
NM_002740, BC022016,
Species
human
UniGene ID
Hs.478199
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.