human PRKAA1 Adenovirus

5'-AMP-activated protein kinase catalytic subunit alpha-1; 5'-AMP-activated protein kinase, catalytic alpha-1 chain; ACACA kinase; acetyl-CoA carboxylase kinase; AMP -activate kinase alpha 1 subunit; AMP-activated protein kinase, catalytic, alpha-1; AMPK; AMPK alpha 1; AMPK subunit alpha-1; AMPKa1; HMGCR kinase; hydroxymethylglutaryl-CoA reductase kinase; protein kinase, AMP-activated, alpha 1 catalytic subunit; tau-protein kinase PRKAA1

AMP-activated protein kinase (AMPK) is a heterotrimeric protein made up of a catalytic alpha subunit, and a regulatory beta and gamma subunit. There are two distinct genes for the alpha subunit, alpha1 and alpha2. AMPK alpha 1 is the serine/threonine kinase catalytic subunit of the AMPK. AMPK is responsible for regulating fatty acid and cholesterol synthesis. AMPK is activated in response to a wide variety of metabolic stresses and switches off anabolic pathways when ATP levels are depleted.

PRKAA1 belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

5562

protein kinase AMP-activated catalytic subunit alpha 1

protein kinase AMP-activated catalytic subunit alpha 1

PRKAA1

HGNC:9376

9606.0

1653

1653 bp

5'-AMP-activated protein kinase catalytic subunit alpha-1

NM_006251

NM_206907, NM_006251, BC048980, BC037303,

Apoptosis,Autophagy,BDNF Signaling,Cardiology,Cardiomyopathy,Cardiovascular,Cell Cycle,EGFR Signaling,EPO Signaling,Hypoxia,IGF-1 Signaling,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Leptin Signaling,LKB1 Signaling,Metabolism/Metabolic Process,mTOR Signaling,Neurobiology,PI3K/Akt Signaling,Signal Transduction,Transcription Factor/Regulator,VEGF Signaling,Wnt Signaling

cardiovascular,cell_biology,cell_cycle,genetics,immunology,metabolism,neurobiology,signal_transduction,transcription_translation

human

AMP-activated protein kinase (AMPK) is a heterotrimeric protein made up of a catalytic alpha subunit, and a regulatory beta and gamma subunit. There are two distinct genes for the alpha subunit, alpha1 and alpha2. AMPK alpha 1 is the serine/threonine kinase catalytic subunit of the AMPK. AMPK is responsible for regulating fatty acid and cholesterol synthesis. AMPK is activated in response to a wide variety of metabolic stresses and switches off anabolic pathways when ATP levels are depleted.

Hs.43322

Q13131