human PICALM Adenovirus

Name 
Ad-h-PICALM
Cat No 
ADV-218895
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human PICALM.

ADV-218895
Ad-h-PICALM

Ready-to-use Adenovirus expressing Human PICALM (phosphatidylinositol binding clathrin assembly protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CALM; clathrin assembly lymphoid myeloid leukemia protein; CLTH; LAP; phosphatidylinositol-binding clathrin assembly protein
Description (eCommerce)
PICALM/CALM is a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. PICALM/CALM is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction [taken from NCBI Entrez Gene (Gene ID: 8301)].
Description (Vector)
PICALM encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
8301
Gene Name (eCommerce)
phosphatidylinositol binding clathrin assembly protein
Gene Name (Vector)
phosphatidylinositol binding clathrin assembly protein
Gene Symbol
PICALM
HGNC ID
HGNC:15514
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1959
ORF Size (bp)
1959 bp
Protein Name (eCommerce)
Phosphatidylinositol-binding clathrin assembly protein
RefSeq ID
NM_007166
RefSeq Synonyms
NM_007166, NM_001206947, NM_001206946, NM_001008660, BC073961, BC064357, BC048259,
Research Areas
Axonogenesis,Cancer,Golgi Apparatus,Immunology,Neurobiology
Research Areas (Faceted)
cancer,neurobiology,developmental_biology,cell_biology,immunology,neurobiology
Species
human
Target Sentence
PICALM/CALM is a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. PICALM/CALM is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction [taken from NCBI Entrez Gene (Gene ID: 8301)].
UniGene ID
Hs.163893
UniProt ID (eCommerce)
Q13492

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.