human PHF21A Adenovirus

Name 
Ad-h-PHF21A
Cat No 
ADV-218815
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human PHF21A.

ADV-218815
Ad-h-PHF21A

Ready-to-use Adenovirus expressing Human PHF21A (PHD finger protein 21A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
BHC80; BHC80a; BM-006; BRAF35/HDAC2 complex (80 kDa); BRAF35-HDAC complex protein BHC80; PHD finger protein 21A
Description (eCommerce)
PHF21A (PHD finger protein 21A) is a component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, PHF21A may act as a scaffold [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9Y6X8].
Description (Vector)
The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 (PubMed 12032298)).(supplied by OMIM, Nov 2010)
Gene ID
51317
Gene Name (eCommerce)
PHD finger protein 21A
Gene Name (Vector)
PHD finger protein 21A
Gene Symbol
PHF21A
HGNC ID
HGNC:24156
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2043
ORF Size (bp)
2043 bp
Protein Name (eCommerce)
PHD finger protein 21A
RefSeq ID
NM_016621
RefSeq Synonyms
NM_016621, NM_001101802, BC015714,
Research Areas
Chromatin Remodeling,Histone Modification,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
PHF21A (PHD finger protein 21A) is a component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, PHF21A may act as a scaffold [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9Y6X8].
UniGene ID
Hs.502458
UniProt ID (eCommerce)
Q96BD5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.