human PDCD4 Adenovirus

Name
Ad-h-PDCD4

Cat No
ADV-218441

Availability
4-5 weeks

This is an Adenovirus expressing Human PDCD4.

ADV-218441

Ad-h-PDCD4

Ready-to-use Adenovirus expressing Human PDCD4 (programmed cell death 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

H731; neoplastic transformation inhibitor protein; nuclear antigen H731; Nuclear antigen H731-like; programmed cell death 4 (neoplastic transformation inhibitor); programmed cell death protein 4; protein 197/15a

Description (eCommerce)

Programmed cell death 4 (PDCD4) has been identified as a tumor suppressor that is able to inhibit tumor invasion and neoplastic transformation. The tumor suppressor activity of PDCD4 is achieved via its ability to inhibit translation initiation of proteins essential for transformation and tumor invasion. PDCD4A inhibits translation by interacting with the RNA helicase eIF4A and the scaffolding protein eIF4G.

Description (Vector)

PDCD4 is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants.

Gene ID

27250

Gene Name (eCommerce)

programmed cell death 4

Gene Name (Vector)

programmed cell death 4

Gene Symbol

PDCD4

HGNC ID

HGNC:8763

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1410

ORF Size (bp)

1410 bp

Protein Name (eCommerce)

Programmed cell death protein 4

RefSeq ID

NM_014456

RefSeq Synonyms

NM_145341, NM_014456, NM_001199492, BC031049, BC026104,

Research Areas

Aging,Apoptosis,Cancer,Cell Cycle,IFN Signaling,Immunology,JNK Signaling,MicroRNAs in Cancer,mTOR Signaling,RNA Binding,RNA Processing,Signal Transduction,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins

Research Areas (Faceted)

cancer,cell_biology,cell_cycle,genetics,immunology,signal_transduction,transcription_translation

Species

human

Target Sentence

Programmed cell death 4 (PDCD4) has been identified as a tumor suppressor that is able to inhibit tumor invasion and neoplastic transformation. The tumor suppressor activity of PDCD4 is achieved via its ability to inhibit translation initiation of proteins essential for transformation and tumor invasion. PDCD4A inhibits translation by interacting with the RNA helicase eIF4A and the scaffolding protein eIF4G.

UniGene ID

Hs.711490

UniProt ID (eCommerce)

Q53EL6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.