human PCGF2 Adenovirus

Name 
Ad-h-PCGF2
Cat No 
ADV-218372
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human PCGF2.

ADV-218372
Ad-h-PCGF2

Ready-to-use Adenovirus expressing Human PCGF2 (polycomb group ring finger 2). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
DNA-binding protein Mel-18; MEL-18; polycomb group RING finger protein 2; ring finger protein 110; RNF110; zinc finger protein 144; ZNF144
Description (eCommerce)
Mel18 is a transcriptional repressor and binds specifically to the DNA sequence 5'-GACTNGACT-3'. Mel-18 is a component of a polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. Mel-18 has tumor suppressor activity. Mel-18 plays a role in control of cell proliferation and/or neural cell development, and also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P35227].
Description (Vector)
PCGF2 contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.
Gene ID
7703
Gene Name (eCommerce)
polycomb group ring finger 2
Gene Name (Vector)
polycomb group ring finger 2
Gene Symbol
PCGF2
HGNC ID
HGNC:12929
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1035
ORF Size (bp)
1035 bp
Protein Name (eCommerce)
Polycomb group RING finger protein 2
RefSeq ID
NM_007144
RefSeq Synonyms
NM_007144, BC024255, BC004858,
Research Areas
Apoptosis,Complexome,Histone Modification,Polycomb Proteins,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
Mel18 is a transcriptional repressor and binds specifically to the DNA sequence 5'-GACTNGACT-3'. Mel-18 is a component of a polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. Mel-18 has tumor suppressor activity. Mel-18 plays a role in control of cell proliferation and/or neural cell development, and also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P35227].
UniGene ID
Hs.371617
UniProt ID (eCommerce)
P35227

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.