human NSD1 Adenovirus

Name 
Ad-h-NSD1
Cat No 
ADV-217109
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human NSD1.

ADV-217109
Ad-h-NSD1

Ready-to-use Adenovirus expressing Human NSD1 (nuclear receptor binding SET domain protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
androgen receptor coactivator 267 kDa protein; androgen receptor-associated coregulator 267; androgen receptor-associated protein of 267 kDa; ARA267; H3-K36-HMTase; H4-K20-HMTase; histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific; KMT3B; lysine N-methyltransferase 3B; NR-binding SET domain-containing protein; nuclear receptor SET domain-containing protein 1; nuclear receptor-binding SET domain-containing protein 1; SOTOS; SOTOS1; STO
Description (eCommerce)
NSD1 is a histone methyltransferase that preferentially methylates Lys-36 of histone H3 and Lys-20 of histone H4. NSD1 can function as an androgen receptor coactivator and is capable of both negatively and positively influencing transcription. Mutations in NSD1 are responsible for Sotos syndrome, Weaver syndrome, Beckwith-Wiedemann syndrome, and a form of childhood leukemia.
Description (Vector)
NSD1 encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.
Gene ID
64324
Gene Name (eCommerce)
nuclear receptor binding SET domain protein 1
Gene Name (Vector)
nuclear receptor binding SET domain protein 1
Gene Symbol
NSD1
HGNC ID
HGNC:14234
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
7284
ORF Size (bp)
7284 bp
Protein Name (eCommerce)
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
RefSeq ID
NM_022455
RefSeq Synonyms
NM_172349, NM_022455, BC150628,
Research Areas
Cancer,Chromatin Remodeling,Estrogen Signaling,Histone Modification,Methyltransferase,Neurobiology,Nuclear Receptor Coactivators,Signal Transduction,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,transcription_translation,signal_transduction,genetics,cell_biology,neurobiology
Species
human
Target Sentence
NSD1 is a histone methyltransferase that preferentially methylates Lys-36 of histone H3 and Lys-20 of histone H4. NSD1 can function as an androgen receptor coactivator and is capable of both negatively and positively influencing transcription. Mutations in NSD1 are responsible for Sotos syndrome, Weaver syndrome, Beckwith-Wiedemann syndrome, and a form of childhood leukemia.
UniGene ID
Hs.106861
UniProt ID (eCommerce)
Q96L73

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.