human NOS3 Adenovirus

Name 
Ad-h-NOS3
Cat No 
ADV-216906
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human NOS3.

ADV-216906
Ad-h-NOS3

Ready-to-use Adenovirus expressing Human NOS3 (nitric oxide synthase 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
cNOS; constitutive NOS; ECNOS; EC-NOS; endothelial NOS; eNOS; nitric oxide synthase 3 (endothelial cell); nitric oxide synthase 3 transcript variant eNOS-delta20; nitric oxide synthase 3 transcript variant eNOS-delta20-21; nitric oxide synthase 3 transcript variant eNOS-delta21; nitric oxide synthase, endothelial; NOS type III; NOSIII
Description (eCommerce)
endothelial nitric oxide synthase (eNOS) is one of four major isoforms of nitric oxide synthase (NOS). The four isoforms, neuronal NOS, endothelial NOS, inducible NOS, and mitochondrial NOS, catalyze the synthesis of nitric oxide (NO) from L-arginine and oxygen. NO is a small free radical that functions as a key signaling molecule in the cardiovascular and neural systems. eNOS is responsible for most of the NO production in the vascular system where it mediates smooth muscle relaxation, angiogenesis, and clotting.
Description (Vector)
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
4846
Gene Name (eCommerce)
nitric oxide synthase 3
Gene Name (Vector)
nitric oxide synthase 3
Gene Symbol
NOS3
HGNC ID
HGNC:7876
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3612
ORF Size (bp)
3612 bp
Protein Name (eCommerce)
Nitric oxide synthase, endothelial
RefSeq ID
NM_000603
RefSeq Synonyms
NM_001160111, NM_001160110, NM_001160109, NM_000603, BC069465, BC063294,
Research Areas
Aging,Angiogenesis,Apoptosis,Cancer,Cardiology,Cardiovascular,Cytoskeleton,EGFR Signaling,Estrogen Signaling,Golgi Apparatus,HIF-1 Signaling,Hypoxia,Leptin Signaling,Metabolism/Metabolic Process,PI3K/Akt Signaling,Signal Transduction,VEGF Signaling
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,developmental_biology,cell_biology,cardiovascular,signal_transduction,cell_biology,metabolism,signal_transduction,signal_transduction
Species
human
Target Sentence
endothelial nitric oxide synthase (eNOS) is one of four major isoforms of nitric oxide synthase (NOS). The four isoforms, neuronal NOS, endothelial NOS, inducible NOS, and mitochondrial NOS, catalyze the synthesis of nitric oxide (NO) from L-arginine and oxygen. NO is a small free radical that functions as a key signaling molecule in the cardiovascular and neural systems. eNOS is responsible for most of the NO production in the vascular system where it mediates smooth muscle relaxation, angiogenesis, and clotting.
UniGene ID
Hs.647092
UniProt ID (eCommerce)
P29474

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.