human MTA2 Adenovirus

Name
Ad-h-MTA2

Cat No
ADV-215965

Availability
4-5 weeks

This is an Adenovirus expressing Human MTA2.

ADV-215965

Ad-h-MTA2

Ready-to-use Adenovirus expressing Human MTA2 (metastasis associated 1 family member 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

metastasis -associated gene 1-like 1; metastasis associated gene family, member 2; metastasis-associated 1-like 1; metastasis-associated protein 2; metastasis-associated protein MTA2; MTA1L1; MTA1-L1 protein; p53 target protein in deacetylase complex; PID

Description (eCommerce)

MTA2 (metastasis-associated protein 2) is a component of the NuRD (nucleosome remodeling and histone deacetylation) complex. MTA2 is highly similar to MTA1 and was identified as a factor differentially expressed in a carcinoma cell line. MTA2 can repress p53-dependent transcriptional activation by enhancing its deacetylation. MTA1 has also been shown to function as a corepressor for ligand-induced estrogen receptor (ER) transactivation. As part of the NuRD complex MTA2 represses ERalpha transactivation activity by modulating the acetylation status of ERalpha.

Description (Vector)

MTA2 encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.

Gene ID

9219

Gene Name (eCommerce)

metastasis associated 1 family member 2

Gene Name (Vector)

metastasis associated 1 family member 2

Gene Symbol

MTA2

HGNC ID

HGNC:7411

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2007

ORF Size (bp)

2007 bp

Protein Name (eCommerce)

Metastasis-associated protein MTA2

RefSeq ID

NM_004739

RefSeq Synonyms

NM_004739, NM_001330292, BC053650,

Research Areas

Cancer,Chromatin Remodeling,EGFR Signaling,Histone Modification,RNA Binding,Signal Transduction,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins,Zinc-finger

Research Areas (Faceted)

cancer,signal_transduction,cell_biology,transcription_translation,signal_transduction,genetics,transcription_translation,cancer,cell_biology

Species

human

Target Sentence

UniGene ID

Hs.173043

UniProt ID (eCommerce)

O94776

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.