human MNT Adenovirus

Name
Ad-h-MNT

Cat No
ADV-215618

Availability
4-5 weeks

This is an Adenovirus expressing Human MNT.

ADV-215618

Ad-h-MNT

Ready-to-use Adenovirus expressing Human MNT (MAX network transcriptional repressor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

bHLHd3; class D basic helix-loop-helix protein 3; MAD6; MAX binding protein; max-binding protein MNT; Max-interacting protein; MNT, MAX dimerization protein; MXD6; myc antagonist MNT; Protein ROX; ROX

Description (eCommerce)

Max-binding protein MNT binds DNA as a heterodimer with MAX and represses transcription. MNT binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3' [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q99583].

Description (Vector)

The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain.

Gene ID

4335

Gene Name (eCommerce)

MAX network transcriptional repressor

Gene Name (Vector)

MAX network transcriptional repressor

Gene Symbol

MNT

HGNC ID

HGNC:7188

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1749

ORF Size (bp)

1749 bp

Protein Name (eCommerce)

Max-binding protein MNT

RefSeq ID

NM_020310

RefSeq Synonyms

NM_020310, BC117563,

Research Areas

Aging,Apoptosis,Cell Cycle,Transcription Factor/Regulator

Research Areas (Faceted)

cell_biology,cell_cycle,genetics,transcription_translation

Species

human

Target Sentence

Max-binding protein MNT binds DNA as a heterodimer with MAX and represses transcription. MNT binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3' [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q99583].

UniGene ID

Hs.632239

UniProt ID (eCommerce)

Q99583

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.