human MAP3K4 Adenovirus

dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4); MAP three kinase 1; MAP/ERK kinase kinase 4; MAPK/ERK kinase kinase 4; MAPKKK4; MEK kinase 4; MEKK 4; MEKK4; mitogen-activated protein kinase kinase kinase 4; MTK1; predicted protein of HQ0412; PRO0412; SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of

Mitogen-activated protein kinase kinase kinase 4 (MEKK4) is a component of a protein kinase signal transduction cascade. MEKK4 activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y6R4].

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described.

4216

mitogen-activated protein kinase kinase kinase 4

mitogen-activated protein kinase kinase kinase 4

MAP3K4

HGNC:6856

9606.0

4677

4677 bp

Mitogen-activated protein kinase kinase kinase 4

NM_005922

NM_006724, NM_005922, NM_001301072, NM_001291958, BC146770, BC143735, BC136276,

Cancer,DNA Damage/Repair,EGFR Signaling,GnRH Signaling,Insulin Signaling,Interleukin Signaling,JNK Signaling,Kinase/Phosphatase,MAPK Signaling,Signal Transduction

cancer,cell_biology,genetics,immunology,signal_transduction,transcription_translation

human

Mitogen-activated protein kinase kinase kinase 4 (MEKK4) is a component of a protein kinase signal transduction cascade. MEKK4 activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y6R4].

Hs.390428

Q9Y6R4