human MAGEL2 Adenovirus

Name
Ad-h-MAGEL2

Cat No
ADV-214846

Availability
4-5 weeks

This is an Adenovirus expressing Human MAGEL2.

ADV-214846

Ad-h-MAGEL2

Ready-to-use Adenovirus expressing Human MAGEL2 (MAGE family member L2). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

NDNL1; nM15; PWLS; SHFYNG

Description (Vector)

Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS.

Gene ID

54551

Gene Name (Vector)

MAGE family member L2

Gene Symbol

MAGEL2

HGNC ID

HGNC:6814

ORF Size (aa)

1941

ORF Size (bp)

1941 bp

RefSeq ID

NM_019066

RefSeq Synonyms

NM_019066, BC167825,

Species

human

UniGene ID

Hs.141496

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.