human KDM4A Adenovirus

Name 
Ad-h-KDM4A
Cat No 
ADV-212841
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human DDX4.

ADV-212841
Ad-h-KDM4A

Ready-to-use Adenovirus expressing Human KDM4A (lysine demethylase 4A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
JHDM3A; jmjC domain-containing histone demethylation protein 3A; JMJD2; JMJD2A; jumonji C domain-containing histone demethylase 3A; jumonji domain containing 2; jumonji domain containing 2A; jumonji domain-containing protein 2A; lysine (K)-specific demethylase 4A; lysine-specific demethylase 4A; TDRD14A; tudor domain containing 14A
Description (eCommerce)
JMJD2A is a member of the jumonji (jmj) domain containing gene family of histone demethylases that plays a role in chromatin regulation and influences transcriptional activation and suppression. Some recently characterized members of the jmj family include JARID1A/RBP2, JARID1C, JMJD1A, JMJD1B, JMJD1C, JMJD2A, JMJD2C and JMJD2D. JMJD2A is a trimethylation-specific demethylase and functions as a transcriptional repressor. JMJD2A interacts with pRb and class one histone deacetylases to mediate repression of E2F-regulated promoters.
Description (Vector)
KDM4A is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.
Gene ID
9682
Gene Name (eCommerce)
lysine demethylase 4A
Gene Name (Vector)
lysine demethylase 4A
Gene Symbol
KDM4A
HGNC ID
HGNC:22978
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3195
ORF Size (bp)
3195 bp
Protein Name (eCommerce)
Lysine-specific demethylase 4A
RefSeq ID
NM_014663
RefSeq Synonyms
NM_014663, BC002558,
Research Areas
Cancer,Chromatin Remodeling,Histone Modification,Host-Virus Interactions,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,transcription_translation,genetics,infectious_disease,genetics,transcription_translation,cell_biology
Species
human
Target Sentence
JMJD2A is a member of the jumonji (jmj) domain containing gene family of histone demethylases that plays a role in chromatin regulation and influences transcriptional activation and suppression. Some recently characterized members of the jmj family include JARID1A/RBP2, JARID1C, JMJD1A, JMJD1B, JMJD1C, JMJD2A, JMJD2C and JMJD2D. JMJD2A is a trimethylation-specific demethylase and functions as a transcriptional repressor. JMJD2A interacts with pRb and class one histone deacetylases to mediate repression of E2F-regulated promoters.
UniGene ID
Hs.155983
UniProt ID (eCommerce)
O75164

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.