human KDM2A Adenovirus

Name 
Ad-h-KDM2A
Cat No 
ADV-212834
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human KDM2A.

ADV-212834
Ad-h-KDM2A

Ready-to-use Adenovirus expressing Human KDM2A (lysine demethylase 2A). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Histone-H3-lysine-36 demethylase 1A; CXXC8; CXXC-type zinc finger protein 8; FBL11; FBL7; F-box and leucine-rich repeat protein 11; F-box protein FBL7; F-box protein Lilina; F-box/LRR-repeat protein 11; FBXL11; JHDM1A; jmjC domain-containing histone demethylation protein 1A; jumonji C domain-containing histone demethylase 1A; LILINA; lysine (K)-specific demethylase 2A; lysine-specific demethylase 2A
Description (eCommerce)
JHDM1A is a member of the JHDM1 histone demethylase family that contains JmjC domains and regulates transcription. It is also a member of the F-box family of proteins which are components of the SKP1-cullin-F-box (SCF) ubiquitin-protein ligase complex. In addition to the JmjC and F-box domains, JHDM1A also contains a CXXC-type zinc-finger, a PHD-type zinc-finger, and 3 LRR (leucine-rich) repeats.
Description (Vector)
KDM2A encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants.
Gene ID
22992
Gene Name (eCommerce)
lysine demethylase 2A
Gene Name (Vector)
lysine demethylase 2A
Gene Symbol
KDM2A
HGNC ID
HGNC:13606
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3489
ORF Size (bp)
3489 bp
Protein Name (eCommerce)
Lysine-specific demethylase 2A
RefSeq ID
NM_012308
RefSeq Synonyms
NM_012308, NM_001256405, BC064360, BC047486, BC047371,
Research Areas
Cancer,Histone Modification,Transcription Factor/Regulator,Ubiquitination,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,transcription_translation
Species
human
Target Sentence
JHDM1A is a member of the JHDM1 histone demethylase family that contains JmjC domains and regulates transcription. It is also a member of the F-box family of proteins which are components of the SKP1-cullin-F-box (SCF) ubiquitin-protein ligase complex. In addition to the JmjC and F-box domains, JHDM1A also contains a CXXC-type zinc-finger, a PHD-type zinc-finger, and 3 LRR (leucine-rich) repeats.
UniGene ID
Hs.124147
UniProt ID (eCommerce)
Q9Y2K7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.