human IQGAP1 Adenovirus
This is an Adenovirus expressing Human IQGAP1.
ADV-212379
Ad-h-IQGAP1
Ready-to-use Adenovirus expressing Human IQGAP1 (IQ motif containing GTPase activating protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HUMORFA01; p195; ras GTPase-activating-like protein IQGAP1; RasGAP-like with IQ motifs; SAR1
Description (eCommerce)
IQGAP1 (IQ motif containing GTPase activating protein 1) interacts with the Rho-family GTPases, CDC42 and RAC1. It has been shown to localize to sites of cell-cell contact and regulate cadherin-mediated cell-cell adhesion. In addition to its role in cell adhesion, it is also involved in cell polarization and migration.
Description (Vector)
IQGAP1 encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines.
Gene ID
8826
Gene Name (eCommerce)
IQ motif containing GTPase activating protein 1
Gene Name (Vector)
IQ motif containing GTPase activating protein 1
Gene Symbol
IQGAP1
HGNC ID
HGNC:6110
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4974
ORF Size (bp)
4974 bp
Protein Name (eCommerce)
Ras GTPase-activating-like protein IQGAP1
RefSeq ID
NM_003870
RefSeq Synonyms
NM_003870, BC151834, BC139731,
Research Areas
Angiogenesis,Cancer,Cytoskeleton,EGFR Signaling,Metabolism/Metabolic Process,Neurobiology,Neurodevelopment,PDGF Signaling,RAC1 Signaling,Signal Transduction,Translational Control,VEGF Signaling
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,metabolism,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
IQGAP1 (IQ motif containing GTPase activating protein 1) interacts with the Rho-family GTPases, CDC42 and RAC1. It has been shown to localize to sites of cell-cell contact and regulate cadherin-mediated cell-cell adhesion. In addition to its role in cell adhesion, it is also involved in cell polarization and migration.
UniGene ID
Hs.430551
UniProt ID (eCommerce)
P46940
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.