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human ING3 Adenovirus

Name 
Ad-h-ING3
Cat No 
ADV-212264
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human ING3.

ADV-212264
Ad-h-ING3

Ready-to-use Adenovirus expressing Human ING3 (inhibitor of growth family member 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Eaf4; ING2; MEAF4; p47ING3
Description (Vector)
ING3 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.
Gene ID
54556
Gene Name (Vector)
inhibitor of growth family member 3
Gene Symbol
ING3
HGNC ID
HGNC:14587
ORF Size (aa)
1257
ORF Size (bp)
1257 bp
RefSeq ID
NM_019071
RefSeq Synonyms
NM_198267, NM_019071, BC153171, BC146417, BC073865,
Species
human
UniGene ID
Hs.489811

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.