human IL4 Adenovirus

Name 
Ad-h-IL4
Cat No 
ADV-212192
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human IL4.

ADV-212192
Ad-h-IL4

Ready-to-use Adenovirus expressing Human IL4 (interleukin 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
B cell growth factor 1;B_cell stimulatory factor 1;B-cell stimulatory factor 1;BCGF1;BCGF-1;binetrakin;BSF1;BSF-1;IL-4;interleukin 4 variant 2;interleukin-4;lymphocyte stimulatory factor 1;pitrakinra
Description (eCommerce)
IL-4 is a pleiotropic cytokine produced by activated T cells. It acts by binding to the interleukin 4 receptor and STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. IL-4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation. In an allergic response, IL-4 has an essential role in the production of allergen-specific immunoglobin (Ig) E. [provided by RefSeq, Aug 2020] [taken from NCBI Entrez Gene (Gene ID: 3565)].
Description (Vector)
IL4 is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Gene ID
3565
Gene Name (eCommerce)
interleukin 4
Gene Name (Vector)
interleukin 4
Gene Symbol
IL4
HGNC ID
HGNC:6014
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
462
Protein Name (eCommerce)
Interleukin-4
RefSeq ID
NM_000589
RefSeq Synonyms
NM_172348, NM_000589, BC070123, BC067515, BC067514, BC066277,
Research Areas
Apoptosis,Fc Receptor Signaling,GPCR Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Interleukin Signaling,JAK-STAT Signaling,Neurobiology,Notch Signaling,PI3K/Akt Signaling,Signal Transduction,T Cell Receptor Signaling
Research Areas (Faceted)
cell_biology,developmental_biology,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
IL-4 is a pleiotropic cytokine produced by activated T cells. It acts by binding to the interleukin 4 receptor and STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. IL-4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation. In an allergic response, IL-4 has an essential role in the production of allergen-specific immunoglobin (Ig) E. [provided by RefSeq, Aug 2020] [taken from NCBI Entrez Gene (Gene ID: 3565)].
UniGene ID
Hs.73917
UniProt ID (eCommerce)
P05112

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.