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human IFNAR1 Adenovirus

Name 
Ad-h-IFNAR1
Cat No 
ADV-211866
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human IFNAR1.

ADV-211866
Ad-h-IFNAR1

Ready-to-use Adenovirus expressing Human IFNAR1 (interferon alpha and beta receptor subunit 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
alpha-type antiviral protein; AVP; beta-type antiviral protein; CRF2-1; cytokine receptor class-II member 1; cytokine receptor family 2 member 1; IFN-alpha/beta receptor 1; IFN-alpha-REC; IFNAR; IFNBR; IFN-R-1; IFRC; interferon (alpha, beta and omega) receptor 1; interferon alpha/beta receptor 1; interferon receptor 1; interferon-alpha/beta receptor alpha chain; interferon-beta receptor 1; type I interferon receptor 1
Description (eCommerce)
Interferon alpha/beta receptor 1 (IFNAR1) associates with IFNAR2 to form the type I interferon receptor. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P17181].
Description (Vector)
IFNAR1 is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.
Gene ID
3454
Gene Name (eCommerce)
interferon alpha and beta receptor subunit 1
Gene Name (Vector)
interferon alpha and beta receptor subunit 1
Gene Symbol
IFNAR1
HGNC ID
HGNC:5432
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1674
ORF Size (bp)
1674 bp
Protein Name (eCommerce)
Interferon alpha/beta receptor 1
RefSeq ID
NM_000629
RefSeq Synonyms
NM_000629, BC021825,
Research Areas
Cytokine Signaling,Host-Virus Interactions,IFN Signaling,Immunology,JAK-STAT Signaling,PI3K/Akt Signaling,Response to Virus,Signal Transduction,T-cell Receptor Signaling,Toll-like Receptor Signaling
Research Areas (Faceted)
immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
Interferon alpha/beta receptor 1 (IFNAR1) associates with IFNAR2 to form the type I interferon receptor. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P17181].
UniGene ID
Hs.529400
UniProt ID (eCommerce)
P17181

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.