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human HERC4 Adenovirus

Name 
Ad-h-HERC4
Cat No 
ADV-210953
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human HERC4.

ADV-210953
Ad-h-HERC4

Ready-to-use Adenovirus expressing Human HERC4 (HECT and RLD domain containing E3 ubiquitin protein ligase 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
HECT domain and RCC1-like domain-containing protein 4; hect domain and RLD 4; HECT-type E3 ubiquitin transferase HERC4; probable E3 ubiquitin-protein ligase HERC4
Description (eCommerce)
HERC4 (HECT domain and RCC1-like domain-containing protein 4) belongs to the HERC family of ubiquitin ligases. In mice, HERC4 expression is ubiquitous with high levels in the testis. Male mice homozygous for HERC4 mutations exhibit reduced fertility and spermatozoa with reduced motility.
Description (Vector)
HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 (PubMed 15676274)).(supplied by OMIM, Mar 2008)
Gene ID
26091
Gene Name (eCommerce)
HECT and RLD domain containing E3 ubiquitin protein ligase 4
Gene Name (Vector)
HECT and RLD domain containing E3 ubiquitin protein ligase 4
Gene Symbol
HERC4
HGNC ID
HGNC:24521
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3150
ORF Size (bp)
3150 bp
Protein Name (eCommerce)
Probable E3 ubiquitin-protein ligase HERC4
RefSeq ID
NM_015601
RefSeq Synonyms
NM_022079, NM_015601, NM_001278187, NM_001278186, NM_001278185, BC039600,
Research Areas
Spermatogenesis,Ubiquitination
Research Areas (Faceted)
cell_biology,developmental_biology
Species
human
Target Sentence
HERC4 (HECT domain and RCC1-like domain-containing protein 4) belongs to the HERC family of ubiquitin ligases. In mice, HERC4 expression is ubiquitous with high levels in the testis. Male mice homozygous for HERC4 mutations exhibit reduced fertility and spermatozoa with reduced motility.
UniGene ID
Hs.51891
UniProt ID (eCommerce)
Q5GLZ8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.