human HBG2 Adenovirus

Name
Ad-h-HBG2

Cat No
ADV-210823

Availability
4-5 weeks

This is an Adenovirus expressing Human HBG2.

ADV-210823

Ad-h-HBG2

Ready-to-use Adenovirus expressing Human HBG2 (hemoglobin subunit gamma 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

HBG-T1; TNCY

Description (Vector)

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'- epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.

Gene ID

3048

Gene Name (Vector)

hemoglobin subunit gamma 2

Gene Symbol

HBG2

HGNC ID

HGNC:4832

ORF Size (aa)

444

RefSeq ID

NM_000184

RefSeq Synonyms

NM_000184, BC130459, BC130457, BC029387,

Species

human

UniGene ID

Hs.302145

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.